Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene. In a document, author is Carlin, S, introducing its new discovery. Safety of 1-Bromo-3-fluoro-2-iodobenzene.
Sodium-iodide symporter (NIS)-mediated accumulation of [(211)AT]astatide in NIS-transfected human cancer cells
The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [At-211]astatide in the UVW human glioma cell line transfected to express NIS. [At-211]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [I-131]iodide uptake. These studies suggest [At-211]astatide as a possible alternative radionuclide to [I-131]iodide for NIS-based endoradiotherapy, and provide a model for the study of [At-211]astatide behavior at a cellular level. (C) 2002 Elsevier Science Inc. All rights reserved.
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