Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 19094-56-5, Name is 2-Chloro-5-iodobenzoic acid, molecular formula is C7H4ClIO2. In an article, author is FUKAYAMA, H,once mentioned of 19094-56-5, COA of Formula: C7H4ClIO2.
EXAMINATION OF ANTITHYROID EFFECTS OF SMOKING PRODUCTS IN CULTURED THYROID-FOLLICLES – ONLY THIOCYANATE IS A POTENT ANTITHYROID AGENT
We studied the antithyroid action of cigarette smoking products (nicotine, cotinine, and thiocyanate) in the physiological culture system of porcine thyroid follicles. Iodide uptake, iodine organification, de novo thyroid hormone formation, and iodide efflux were measured in the presence of 0-200 mumol/l nicotine, cotinine, or potassium thiocyanate. Nicotine and cotinine did not inhibit iodide transport or thyroid hormone formation. Thiocyanate concentrations equivalent to serum levels of smokers showed three independent antithyroid actions: (i) inhibition of iodide transport, (ii) inhibition of iodine organification, and (iii) increased iodide efflux. Inhibition of iodide transport by thiocyanate was competitive with iodide and independent of TSH concentration. Thiocyanate did not inhibit TSH mediated cAMP production or Na+K+ATPase activity, a sodium pump for iodide transport. When 50 mumol/l thiocyanate was added 2 h after incubation with iodide or when 1 mumol/l thiocyanate was added from the beginning of incubation, iodine organification was inhibited without changing iodide transport. De novo thyroid hormone formation was clearly inhibited by 50 mumol/l thiocyanate. Thiocyanate increased iodide efflux although the degrees of iodide efflux by 10 mumol/l and 100 mumol/l thiocyanate did not differ significantly. In summary, thiocyanate, a product of smoking, has three independent antithyroid activities. The data of iodide transport kinetics suggest that thiocyanate can be an antithyroid agent particularly in iodine deficiency.
Interested yet? Keep reading other articles of 19094-56-5, you can contact me at any time and look forward to more communication. COA of Formula: C7H4ClIO2.