In an article, author is Wolf, C, once mentioned the application of 507-63-1, SDS of cas: 507-63-1, Name is Heptadecafluoro-1-iodooctane, molecular formula is C8F17I, molecular weight is 545.9629, MDL number is MFCD00001064, category is iodides-buliding-blocks. Now introduce a scientific discovery about this category.
Acid-mediated halogen exchange in heterocyclic arenes: A highly effective iodination method
Heterocyclic arenes including pyridyl, quinolyl and isoquinolyl chlorides have been converted to their corresponding iodides in good to high yields via acid-mediated nucleophilic halogen exchange with sodium iodide. This procedure avoids the use of transition metals, harsh reaction conditions, and affords highly regioselective halide exchange. Chloride substituents in position 2 and 4 of pyridines and quinolines are readily substituted by iodide in 75-91% and conversion of 1-chloroisoquinoline to its iodide derivative was found to proceed with 90% yield. Positions that are not activated for nucleophilic aromatic substitution proved to be inert to halide exchange. Regioselective chloride/iodide exchange in 4,7-dichloroquinoline hydrochloride gave 7-chloro-4-iodoquinoline, an important precursor of anti-malaria drugs, in almost 90% yield.
If you are interested in 507-63-1, you can contact me at any time and look forward to more communication. SDS of cas: 507-63-1.