Month: March 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111771-08-5, name is 2-Fluoro-6-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 111771-08-5

2-Fluoro-6-iodo-N r4-phenyl-1-(propelsulfonel) piperidin-4-YllmethYl Tbenzamide A mixture of 2-fluoro-6-iodo benzoic acid (54 mg, 0.20 mmol), HOBt (27 mg, 0.20), PS-Carbodiimide (200 mg, 0.24 mmol), DIEA (52 mg, 0.4 mmol), and 1- [4-phenyl-1- (propylsulfonyl) piperidin-4-yl] methanamine (I-3) (30 mg, 0.10 mmol) in DCM (6 mL) was shaken over night at room temperature. Next morning, LCMS indicated that the amine was consumed. The resin was filtered and washed with DCM (4 x 5 mL). The combined DCM solution was concentrated and the residue was purified by LCMS to afford the pure product as a white solid (51 mg, 94%).

According to the analysis of related databases, 111771-08-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2005/46601; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 460-37-7 as follows. HPLC of Formula: C3H4F3I

Example 66A 3-Isobutyl-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 3.23 g (23.39 mmol) of potassium carbonate were added to a solution of 2.23 g (9.35 mmol) of the compound from Ex. 44A in 82.6 ml of DMF, and the mixture was stirred at RT for 15 min. Then 6.48 g (28.07 mmol) of 1,1,1-trifluoro-3-iodopropane were added, and the mixture was stirred at RT for 73 h. The DMF was then very substantially distilled off and the remaining residue was partitioned between semisaturated sodium chloride solution (200 ml) and ethyl acetate (100 ml). The aqueous phase was extracted with ethyl acetate. The combined organic phases were dried over sodium sulphate, filtered and concentrated. The residue obtained was chromatographed using a silica gel cartridge (Biotage, 340 g of silica gel, eluent: hexane/ethyl acetate). In this way, 2.67 g (84% of theory) of the title compound were obtained. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 6.88 (d, 1H), 4.13 (t, 2H), 3.71 (d, 2H), 2.84-2.70 (m, 2H), 2.38 (d, 3H), 2.11-1.96 (m, 1H), 0.85 (d, 6H). LC/MS (Method 3): Rt=1.4 min, m/z=335 [M+H]+.

According to the analysis of related databases, 460-37-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAeRTER, Michael; KOSEMUND, Dirk; DELBECK, Martina; KALTHOF, Bernd; WASNAIRE, Pierre; SUessMEIER, Frank; LUSTIG, Klemens; (369 pag.)US2018/65981; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 186583-59-5, name is 1-Iodo-2-methoxy-4-methylbenzene, A new synthetic method of this compound is introduced below., SDS of cas: 186583-59-5

Compound 12 (7.44 g, 30.0 mmol) in DMSO (20 ml) was added to a suspension of bis(pinacolate)diboron (8.38 g, 33.0 mmol) and pre-dried potassium acetate (8.84 g, 90.0 mmol) and PdCl2(dppf)¡¤CH2Cl2 (735 mg, 0.900 mmol) in DMSO (80 ml) under Ar atmosphere, and the mixture was stirred for 5 h at 80 C. The reaction mixture was diluted with ethyl acetate and filtered through Celite. The organic layer was washed with water and brine, dried with sodium sulfate, and evaporated. Purification by silica gel column chromatography (n-hexane/ethyl acetate 10:1) gave 8 (colorless solids, 6.19 g, 25.0 mmol, 83%). Mp 59.5-60.0 C; 1H NMR (500 MHz, CDCl3) delta 7.55 (d, 1H, J=7.5 Hz), 6.74 (d, 1H, J=7.3 Hz), 6.65 (s, 1H), 3.80 (s, 3H), 2.33 (s, 3H), 1.32 (s, 12H); 13C NMR (125 MHz, CDCl3) delta 164.39, 142.98, 136.81, 120.99, 111.44, 83.20, 55.74, 24.98, 24.77, 21.90; HRMS (FAB+) m/z 248.1697 [(M)+: calcd for C14H22O3B, 248.1584].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Iwashita, Masazumi; Fujii, Shinya; Ito, Shigeru; Hirano, Tomoya; Kagechika, Hiroyuki; Tetrahedron; vol. 67; 33; (2011); p. 6073 – 6082;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 7681-82-5

Synthesis of 47; A Schlenk tube was charged with complex 46 (67.7 mg, 0.17 mmol), Nal (509.7 mg, 3.4 mmol), and 5 mL of THF. The reaction mixture was stirred at room temperature for 8 h. The solvent was removed under vacuum. The residue was dissolved in toluene, and the resulting suspension was passed through a plug of Celite. All the volatiles were removed, and the residue was washed with diethyl ether (3 x 5 mL) to give 47 as a dark red powder. Yield: 70% (69.8 mg, 0.12 mmol).1H NMR (CD2C12, 400 MHz): delta 7.08 (s, 2H,CHimid), 5.59 (d, J=5.60 Hz, 2H, CHpcym), 5.18 (d, J = 5.56 Hz, 2H, CHpcym), 4.04 (s, 6H, CH3imid), 3.15 (septet, J = 6.88 Hz, 1H, CHisop pcym), 1.96 (s, 3H, CH3pcym), 1.23 (d, J=6.88 Hz, 6H, CH3isop pcym).13C NMR (CD2C12, 100MHz): delta 170.4 (C-Ru), 124.4 (CH^a), 110.0 (Cqpcym), 99.9(Cqpcym), 86.6 (CHpcym), 83.0 (CHpcym), 44.9 32.0 (CHisop pcym), 23.0 (CH3is0p pCym),-19.2 (CH3pcym).Anal, calcd for C16H24Cl2I2N2Ru (47 3CH2C12, 670.2): C, 28.68; H, 3.61; N, 4.18. Found: C, 28.41; H, 3.89; N, 4.33

The synthetic route of Sodium iodide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANYANG TECHNOLOGICAL UNIVERSITY; HONG, Soon Hyeok; GHOSH, Subhash Chandra; ZHANG, Yao; MUTHAIAH, Senthilkumar; CHEN, Cheng; XU, Xiangya; WO2011/34506; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 31827-94-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The appropriate carbonyl compound (50 mmol) was dissolved in 50 mL of ethanol and magnetically stirred with an equimolar quantity of thiosemicarbazide for 24 h at room temperature with catalytic amounts of acetic acid. The desired thiosemicarbazone precipitated from reaction mixture, was filtered, crystallized from suitable solvent, and dried. Equimolar quantities of 4-iodo-acetophenone and bromine, both dissolved in chloroform, were stirred for 4 h at room temperature until the presence of HBr disappeared. The solution was evaporated under vacuum and the obtained pale yellow solid was washed with petroleum ether to give alpha-bromo-4-iodo-acetophenone in good yield (94%). Equimolar amounts of the prepared thiosemicarbazone (50 mmol) and alpha-bromo-4-iodo-acetophenone (50 mmol), both suspended in 50 mL of ethanol, were reacted at room temperature under magnetic stirring for 10 h. The precipitate was filtered and purified by chromatography to give compounds 1-25 in high yield.

The synthetic route of 2-Bromo-1-(4-iodophenyl)ethanone has been constantly updated, and we look forward to future research findings.

Reference:
Article; Secci, Daniela; Bizzarri, Bruna; Bolasco, Adriana; Carradori, Simone; D’Ascenzio, Melissa; Rivanera, Daniela; Mari, Emanuela; Polletta, Lucia; Zicari, Alessandra; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 246 – 253;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3032-81-3

General procedure: [(Cinnamyl)PdCl]2 (5 mol percent) and AsPh3 (10 mol percent) were transferred into a vial (4 mL reaction volume) equipped with a septum, a small cannula and a stirring bar. After the vials were purged with argon, 1,4-dioxane distilled from sodium ketyl, 2 ml, iodobenzene (1 mmol), and HMDS (2 mmol) were injected into the vial by syringe. Then, the vial was placed in an alloy plate, which was transferred into a 300 mL autoclave of the 4560 series from Parr Instruments.(R). under argon atmosphere. After flushing the autoclave three times with CO, a pressure of 10 bar was adjusted and the reaction was performed for 16 h at 110 ¡ãC. Due to the sensitivity of the products no isolation was performed and characterization was done by GC-MS. Determination of the yield was done using the calibration factor of benzoyltrimethyl silane.

According to the analysis of related databases, 3032-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias; Tetrahedron Letters; vol. 53; 5; (2012); p. 582 – 584;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 25245-35-6, These common heterocyclic compound, 25245-35-6, name is 2-Iodo-1,4-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd (II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 ¡Á 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product was subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

Statistics shows that 2-Iodo-1,4-dimethoxybenzene is playing an increasingly important role. we look forward to future research findings about 25245-35-6.

Reference:
Article; Csuk, Rene; Albert, Sabrina; Siewert, Bianka; Schwarz, Stefan; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 669 – 678;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 622-50-4, These common heterocyclic compound, 622-50-4, name is N-(4-Iodophenyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Under Oxygen, a reaction tube was charged with p-iodoanisole (46.3 mg, 0.2 mmol), urea (48.0 mg, 0.8 mmol), CuF2 (4.1 mg, 0.04 mmol), L1 (10.8 mg, 0.06 mmol), Li2CO3 (44.3 mg, 0.6mmol) and DMSO (2 mL). The mixture was stirred at 150 oC for 36 h. After the completion of the reaction, monitored by TLC, the solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography on silica gel to give the product.

Statistics shows that N-(4-Iodophenyl)acetamide is playing an increasingly important role. we look forward to future research findings about 622-50-4.

Reference:
Article; Zheng, Kui; Liu, Bin; Chen, Shuyou; Chen, Fan; Tetrahedron Letters; vol. 54; 38; (2013); p. 5250 – 5252;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 103962-05-6, A common heterocyclic compound, 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, molecular formula is C7H4F3IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of alkyne 97 (0.075 g, 0.25 mmol), 1-iodo-4-(trifluoromethoxy)benzene (70) (0.088 g, 0.30 mmol) and copper iodide (5 mg, 0.03 mmol) in DMF (2 mL) and Et3N (2 mL) was purged with N2. PdCl2(PPh3)2 (9 mg, 0.01 mmol) was added and the mixture was stirred at room temperature for 0.5 h, and then partitioned between EtOAc and water. Column chromatography of the organic portion on silica gel using gradient elution (0-5percent MeOH:EtOAc) gave 18 (0.084 g, 73percent) as a white solid: mp 207-208¡ã C.; 1H NMR [(CD3)2SO] delta 8.71 (d, J=1.7 Hz, 1H), 8.03 (s, 1H), 7.99 (dd, J=8.1, 2.2 Hz, 1H), 7.73 (d, J=8.9 Hz, 2H), 7.42-7.47 (m, 3H), 4.81 (d, J=13.9 Hz, 1H), 4.77 (d, J=13.9 Hz, 1H), 4.71 (dt, J=12.0, 2.5 Hz, 1H), 4.51 (d, J=11.9 Hz, 1H), 4.31-4.37 (m, 2H), 4.26 (dd, J=13.7, 3.5 Hz, 1H). Anal. (C21H15F3N4O5) C, H, N.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Global Alliance for TB Drug Development; US2012/28973; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 444-29-1,Some common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, molecular formula is C7H4F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a 25mL of oven-dried Schlenk tube equipped with a magnetic stir bar was charged with [Pd(C3H5)Cl]2 (3.7mg 0.01mmol, 0.05 equiv), XPhos (10.5mg, 0.022mmol, 0.11 equiv), K2CO3 (69.1mg, 0.5mmol, 2.5 equiv), and dry CH3CN (1mL). After stirring for about 15minat r.t. under argon, a solution of aryl iodide 1 (0.24mmol, 1.2 equiv), alkylating reagent 2 (0.2mmol, 1.0 equiv), 5-Norbornene-2-carboxylic acid N4 (5.5mg, 0.04mmol, 0.2 equiv) in dry MeCN (1mL) was added, then heated to 70¡ãC and stirred for 5?24h. The reaction was monitored by TLC, after completion of the reaction, the mixture was cooled to r.t., filtered through a thin pad of celite eluting with ethyl acetate (10mL), and the combined filtrate was concentrated in vacuo. The residue was directly purified by column chromatography on silica gel or purified by PTLC to give the desired product 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-2-(trifluoromethyl)benzene, its application will become more common.

Reference:
Article; Liu, Ze-Shui; Qian, Guangyin; Gao, Qianwen; Wang, Peng; Cheng, Hong-Gang; Hua, Yu; Zhou, Qianghui; Tetrahedron; vol. 75; 12; (2019); p. 1774 – 1780;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com