Chemistry, like all the natural sciences, HPLC of Formula: C7H4F3I, begins with the direct observation of nature¡ª in this case, of matter.455-13-0, Name is 4-Iodobenzotrifluoride, SMILES is C1=C(C(F)(F)F)C=CC(=C1)I, belongs to iodides-buliding-blocks compound. In a document, author is Pan Hongmei, introduce the new discover.
The effects of amitrole on thyroglobulin and iodide uptake in FRTL-5 cells
Thyroid is a frequent target for endocrine effects of pesticides. Thyroglobulin (TG) and iodide uptake are crucial to thyroid hormone synthesis and may be targets of thyroid-disrupting chemicals. In our study, thyroid follicular FRTL-5 cells were treated with amitrole, an inhibitor of the thyroid peroxidase (TPO), and the effects on TG and total iodide uptake were observed. The results showed that 1 – 100 mg/L amitrole had no marked effects on FRTL-5 cell proliferation and DNA synthesis. However, it significantly increased the transcription of tg gene and inhibited the total iodide uptake. And 10 – 100 mg/L amitrole significantly decreased TG in the culture medium. The data suggests amitrole may disrupt the expression and secretion of TG and iodide uptake.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 455-13-0. HPLC of Formula: C7H4F3I.