Related Products of 610-97-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 610-97-9, Name is Methyl 2-iodobenzoate, SMILES is O=C(OC)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Haltner-Ukomadu, Eleonore, introduce new discover of the category.
In Vitro Bioavailability Study of an Antiviral Compound Enisamium Iodide
An investigation into the biopharmaceutics classification and a study of the in vitro bioavailability (permeability and solubility) of the antiviral compound enisamium iodide (4-(benzylcarbamoyl)-1-methylpyridinium iodide) were carried out. The solubility of enisamium iodide was determined in four different buffers. Apparent intestinal permeability (P-app) of enisamium iodide was assessed using human colon carcinoma (Caco-2) cells at three concentrations. The solubility of enisamium iodide in four buffer solutions from pH 1.2 to 7.5 is about 60 mg/mL at 25 degrees C, and ranges from 130 to 150 mg/mL at 37 degrees C, depending on the pH. Based on these results, enisamium iodide can be classified as highly soluble. Enisamium iodide demonstrated low permeability in Caco-2 experiments in all tested concentrations of 10-100 mu M with permeability coefficients between 0.2 x 10(-6) cm s(-1) and 0.3 x 10(-6) cm s(-1). These results indicate that enisamium iodide belongs to class III of the Biopharmaceutics Classification System (BCS) due to its high solubility and low permeability. The bioavailability of enisamium iodide needs to be confirmed in animal and human studies.
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