A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 88-67-5, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 88-67-5, Name is 2-Iodobenzoic acid, molecular formula is C7H5IO2. In an article, author is Panneels, V.,once mentioned of 88-67-5.
Iodide Effects on the Thyroid: Biochemical, Physiological, Pharmacological, and Clinical Effects of Iodide in the Thyroid
Iodide, the main and limiting substrate in the synthesis of thyroid hormones by the thyroid gland, also exerts physiological and pharmacological signaling effects on this organ. In vivo studies in humans and animals have demonstrated that at low or physiological levels (<0.4 mu M), iodide uptake limits the synthesis of thyroid hormones and therefore their secretion. These serum thyroid hormones depress the secretion of the main physiological activator of the gland, pituitary thyroid stimulating hormone (TSH). Thus, iodine deficiency leads to decreased thyroid hormone levels and compensatory TSH secretion. At these levels, there is an inverse relationship between iodide supply and TSH secretion. This is a negative indirect control. At high concentrations (0.4-10 mu M), iodide directly inhibits several activating thyroid signaling pathways. Such effects require an intact follicular structure and the oxidative organification of a postulate intermediate X to XI. Two iodinated lipids reproduce these effects of iodide: iodolactone and 2-iodohexadecanal. Only the latter is found in the thyroid. The direct effects of iodide and XI account for an inhibition of iodide oxidation itself, of iodide uptake, and of thyroid hormone secretion and thyroid growth. Besides the XI effects, iodide at very high pharmacological or toxicological concentrations (>10 mu M) appears to directly inhibit thyroid blood flow and secretion. The latter effects are used in the preoperative treatment of patients suffering from Graves’ disease with Lugol. The various experimental models used to elucidate the direct effects of iodide on the thyroid are discussed and analyzed. The chapter also describes the clinical consequences of the diverse iodide actions
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