Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, in an article , author is Josefsson, Malin, once mentioned of 144-48-9, Formula: C2H4INO.
Sodium Iodide Symporter (NIS) in Gastric Mucosa: Gastric Iodide Secretion
Iodide is actively transported from the bloodstream into the gastric juice and some iodide accumulation occurs in the gastric wall, but no uptake of iodide takes place in the gastric lumen. The cDNA-sequence of the thyroid sodium iodide symporter (NIS) was revealed in 1996 and, in the thyroid gland, iodide is actively transported into the thyrocyte by NIS. Later on NIS was also found to be present, in large amounts, in the gastric mucosa, where it is located basolaterally in the surface epithelial cells. Iodide transport over the gastric mucosa is attenuated by the selective competitive NIS inhibitor perchlorate, and also by ouabain, an inhibitor of Na+/K+-ATPase, which powers NIS transport. Thus, gastric iodide secretion is to a large extent mediated by NIS. The regulation of gastric NIS expression is still unknown. The functional role of NIS in the gastric mucosa is uncertain, but several theories have been put forward. These include mediating recirculation of iodide, as well as securing the presence of iodide in the stomach for antimicrobial or antioxidative purposes. Gastric iodide secretion may also be a protecting mechanism against developing gastric cancer. Gastric NIS has further been suggested to be an important protein for transporting anions other than iodide, i.e., nitrate. In the future NIS expression, or lack thereof, may become a useful parameter in the diagnosis of gastric cancer. Gene transfer of NIS into cancer cells without NIS expression, as well as chemical induction of NIS expression, are methods under exploration. If means to regulate NIS expression in tumor cells are found, it may become possible to use radioiodine therapy in gastric cancer.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 144-48-9, you can contact me at any time and look forward to more communication. Formula: C2H4INO.