Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Quality Control of Methyl 2-iodobenzoate, 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, belongs to iodides-buliding-blocks compound. In a document, author is KENGEN, RAM, introduce the new discover.
I-131 HIPPURAN FOR THE ESTIMATION OF RENAL PLASMA-FLOW – REQUIREMENTS FOR RADIOCHEMICAL PURITY
For many years iodide-131 Hippuran has been used as a tracer to measure effective renal plasma flow (ERPF). Because of the low renal clearance of free I-131-iodide and the inability to count it separately from I-131-Hippuran, free I-131-iodide will lower the calculated I-131-Hippuran clearance, resulting in a lower estimated ERPF. This study was performed to establish the maximum allowable radiochemical impurity of free I-131-iodide in I-131-Hippuran preparations for ERPF measurements in continuous clearance studies. A known amount of I-123-iodide was added to the (I-131-iodide-free) I-131-Hippuran solution used for continuous infusion clearance studies in nine patients. I-123-iodide activity was used because it can be counted separately from (131)-I-Hippuran in the infusion solutions and plasma samples while it behaves exactly like I-131-iodide, so that the results obtained with I-123-iodide can be extrapolated to I-131-iodide. After performing the clearance studies, the ERPF was calculated firstly with I-131-Hippuran activity only (=true ERPF) and secondly including the free radioactive iodide activity (=false ERPF) in the clearance formula, As expected, if free I-131-iodide is present in the infusion solution, its concentration in plasma will be highest at the end of the clearance study. The I-131-iodide concentration in plasma relative to the I-131-Hippuran concentration will be higher in patients with high ERPF values. I-131-iodide in the infusion solution causes a fall in the ERPF as measured by the continuous infusion technique: 0.5%, 1% and 2% of free I-131-iodide in the infusion solution result in a reduction in ERPF of about 1.5%, 3.5% and 7% respectively after 1.5 h and of 3.5%, 6.5% and 13% respectively after 5.5 h if ERPF is high. It is concluded that a maximum of 0.5% of free I-131-iodide in I-131-Hippuran preparations is permissible if ERPF is to be measured with an error of less than 5%.
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