Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene, SMILES is FC1=CC=CC(Br)=C1I, belongs to iodides-buliding-blocks compound. In a document, author is Zhang, L, introduce the new discover, Computed Properties of C6H3BrFI.
Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation
While external ionizing radiation has been used for treating non-small cell lung cancer (NSCLC), improved efficacy of this modality would be an important advance. Ectopic expression of the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes in NSCLC cells facilitated concentration of iodide in NSCLC cells, which markedly induced apoptosis in vitro and in vivo. Preincubation of the NIS/TPO-modified NSCLC cells in iodide followed by ionizing radiation generates bystander tumoricidal effects and potently enhances tumor cell killing. This iodide-induced bystander effect is associated with enhanced gap junction intercellular communication (GJIC) activity and increased connexin-43 (Cx43) expression. Thus, iodide may serve as an enhancer to markedly improve the efficacy of radiation therapy in combined therapeutic modalities.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 450412-29-0 is helpful to your research. Computed Properties of C6H3BrFI.