Synthetic Route of 619-58-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 619-58-9, name is 4-Iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In the inert gas N2 atmosphere, after dehydration and deoxidation treatment to the reaction bottle after adding 4 – iodo benzoic acid (124.0 mg, 0.5 mmol, gun for adding […] borane (290 mul, 2 mmol), reacting at room temperature 12 hours, the reaction out of the glove box, in order to have three methoxybenzene (84.09 mg, 0.5 mmol) as the internal standard, CDCl3 for dissolving, stirring 10 minutes, sampling, with nuclear magnetic resonance. Calculated 1 H and the yield is 99%. The product of nuclear magnetic data: The residue is added to the sample in 1 g silica gel, in order to 3 ml methanol as a solvent, 50 C lower reaction 3 h, the borate further hydrolysis alcohol, after the reaction, extracted with ethyl acetate three times, the combined organic layer, dried with anhydrous sodium sulfate, the solvent is removed under reduced pressure, through the silica gel (100 – 200 mesh) column chromatography purification, ethyl acetate/hexane (1:5) mixture as the eluent, to obtain the pure primary alcohol, separation and the yield is 94%.
The synthetic route of 4-Iodobenzoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Soochow University (Suzhou); Xue Mingqiang; Xu Xiaojuan; Yan Dandan; Kang Zihan; Zhu Zhangye; Shen Qi; (9 pag.)CN109574808; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com