Related Products of 364-75-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 364-75-0 as follows.
A solution of the compound of Example 1(e) (4.6 g, 17.54 mmol), 1-fluoro-4-iodo-2-nitrobenzene of Intermediate Example 3 (4.683 g, 17.54 mmol, 1.0 eq.) and potassium fluoride (1.22 g, 21.05 mmol, 1.2 eq.) in DMF was heated at 130 C. for 5 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off and the crude residue was purified by column chromatography (60-120 silica gel, 50% ethyl acetate in hexane) to give the product in 76% yield (6.8 g). 1H NMR (300 MHz, DMSO-d6): delta 10.15 (br s, 1H), 9.41 (s, 1H), 8.35 (d, 1H), 7.78 (dd, 1H), 7.66-7.54 (m, 3H), 7.39 (m, 1H), 7.22 (m, 1H), 7.14-7.11 (m, 2H), 2.06 (s, 3H).
According to the analysis of related databases, 364-75-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Linnanen, Tero; Wohlfahrt, Gerd; Nanduri, Srinivas; Ujjinamatada, Ravi; Rajagopalan, Srinivasan; Mukherjee, Subhendu; US2015/11548; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com