Related Products of 626-44-8,Some common heterocyclic compound, 626-44-8, name is 1,3,5-Triiodobenzene, molecular formula is C6H3I3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3 (210.4 mg, 0.461 mmol), 4 (0.25 mL, 1.75 mmol), PdCl2(PPh3)2 (48.5 mg, 0.069 mmol), PPh3 (36.3 mg, 0.138 mmol), CuI (13.2 mg, 0.069 mmol), Et3N (2.0 mL), and THF (5.0 mL) was placed in a round-bottom flask equipped with a magnetic stirring bar. After degassing the reaction mixture several times, the reaction was carried out at 40 ¡ãC for 16 h with stirring. After the reaction mixture was cooled to room temperature, CHCl3 was added to the mixture. Precipitates were removed by filtration, and the solvent was evaporated. The residue was purified by SiO2 column chromatography (hexane as an eluent, Rf = 0.15), and crystallization was carried out to afford 5 as a colorless solid (172.5 mg, 0.373 mmol, 81percent).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Triiodobenzene, its application will become more common.
Reference:
Article; Morisaki, Yasuhiro; Gon, Masayuki; Tsuji, Yuichi; Kajiwara, Yuichi; Chujo, Yoshiki; Tetrahedron Letters; vol. 52; 42; (2011); p. 5504 – 5507;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com