The synthetic route of 340825-13-0 has been constantly updated, and we look forward to future research findings.
340825-13-0, name is 6-Iodo-3,4-dihydronaphthalen-1(2H)-one, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 340825-13-0
According to the following reaction formula (scheme),Compound (3) was synthesized. A 200 mL round-bottom flask was charged with Compound (2) (4.1 g, 15 mmol) and methanol (100 mL). Sodiumborohydride (850 mg, 22.5 mmol) was gradually added to the resultant mixture at 0C with ice cooling, followed by stirring for 3 hours at 0C. Subsequently, excessive sodium borohydride was neutralized with dilute hydrochloric acid, and saturated brine was added to the mixture, which was then extracted with ethyl acetate (50 mL) 5 times. The extraction liquid was washed with ammonium chloride (100 mL) once and with brine (100 mL) twice. The reafter, sodium sulfate was added thereto, followed by filtration. The filtrate was concentrated to obtain Compound (3) as a pale red solid (yield amount: 3.93 g, yield rate ^ 95.5%), which was directly used in the next step without any further purification. The analysis results of Compound (3) are shown below.iH NMR (500 MHz, CDC13, TMS, delta) : 1.71 (d, 1H, J = 5.8 Hz), 1.84-2.02 (m, 4H), 2.65-2.71 (m, 1H), 2.75-2.81 (m, 1H), 4.72 (d, 1H, J =4.6 Hz), 7.17 (d, 1H, J = 8.0 Hz), 7.47 (s, 1H), 7.52 (d,t 1H, Ji = 8.0 Hz, J2 = 1.2 Hz) Mass spectrometry: GC-MS m/z = 274 (M+) Melting point: 82.0C-84.0C From the above analysis results, it was confirmed that a structure of the synthesized product did not contradict that of Compound (3).
The synthetic route of 340825-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RICOH COMPANY, LTD.; GOTO, Daisuke; YAMAMOTO, Satoshi; SAGISAKA, Toshiya; KATO, Takuji; TANO, Takanori; SHINODA, Masato; MATSUMOTO, Shinji; MOHRI, Masataka; YUTANI, Keiichiro; WO2011/158953; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com