Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H4F2IN
General procedure: To a solution of iodoaniline 2 (5.00 mmol) and ethynyltrimethylsilane (1.47 g, 15.00 mmol) in Et3N (10 mL) in a Schlenk flask under argon were added Pd(PPh3)2Cl2 (175 mg, 0.25 mmol) and CuI (95 mg, 1.50mmol). The reaction mixture was heated at 40 C for the required period (Table 1) with stirring. Then, the mixture was diluted with CH2Cl2(10 mL). The suspension was placed directly onto a chromatography plate (silica gel) and air-dried. The trimethylsilanyl ethynylanilines 3 were isolated by TLC using EtOAc/hexane as the eluent. 4,5-Difluoro-2-[(trimethylsilyl)ethynyl]aniline (3a) Brown oil; yield: 1.00 g (89%); Rf = 0.56 (EtOAc/hexane, 1:7). IR (neat): 3485, 3388, 2960, 2901, 2148, 1628, 1599, 1516, 1437, 1348, 1298, 1252, 1227, 1182, 1122, 870, 845, 762, 629 cm-1. 1H NMR (300 MHz, acetone-d6): delta = 7.07 [dd, J (H3,F4) = 10.8 Hz, J (H3,F5) = 8.8 Hz, 1 H, H3], 6.63 [dd, J (H6,F5) = 12.7 Hz, J (H6,F4) = 7.1 Hz, 1 H, H6], 5.01 (s, 2 H, NH2), 0.26 (s, 9 H, CH3). 13C NMR (100 MHz, acetone-d6): delta = 152.0 [dd, 1J (C5,F5) = 247.3 Hz, 2J (C5,F4) = 13.8 Hz, C5], 147.9 [d, 3J (C1,F5) = 10.0 Hz, C1], 142.3 [dd,1J (C4,F4) = 235.5 Hz, 2J (C4,F5) = 13.9 Hz, C4], 120.1 [dd, 2J (C3,F4) = 19.0 Hz, 3J (C3,F5) = 2.0 Hz, C3], 103.1 [m, 3J (C2,F4) = 7.2 Hz, C2], 102.8 [d, 2J (C6,F5) = 21.0 Hz, C6], 103.1 (m, C?C), 100.3 (m, C?C), 0.0 (s, CH3). 19F NMR (282 MHz, acetone-d6): delta = -134.4 [ddd, J (F5,F4) = 22 Hz, J (F5,H6) = 12.7 Hz, J (F5,H3) = 8.8 Hz, 1 F, F5], -153.2 [ddd, J (F4,F5) = 22.4 Hz, J (F4,H3) = 10.8 Hz, J (F4,H6) = 7.1 Hz, 1 F, F4]. HRMS (EI): m/z [M]+ calcd for C11H13F2NSi: 225.0780; found: 225.0781.
According to the analysis of related databases, 847685-01-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Politanskaya, Larisa; Tretyakov, Evgeny; Synthesis; vol. 50; 3; (2018); p. 555 – 564;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com