Reference of 444-29-1, The chemical industry reduces the impact on the environment during synthesis 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.
representable procedure for Suzuki reaction of 4-iodomethylbenzene and phenylboronic acid (Table 2, entry 2). The catalyst Pd(at)poly-Sty-co-diOH-Cl (5.5 mg, Pd: 0.05 mol percent), 4-iodomethylbenzene (218 mg, 1 mmol), phenylboronic acid (183 mg, 1.5 mmol), K2CO3 (276 mg, 2 mmol), and ethanol/H2O (3 ml, 2:1, v/v) were added into a 25 ml round bottomed flask, which was then heated to 70 ¡ãC for 1 h as monitored by TLC. After the reaction was finished, the catalyst was filtered and washed three times with ethyl acetate (3 ml). Then, 10 ml water was added to the filtrate, and 10 ml EtOAc was added to extract the organic compound for three times. The combined extract was evaporated to leave the crude products which were purified by column chromatography over silica gel to furnish the pure 4-methylbiphenyl as a white solid:
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Jiayi; Song, Gonghua; Peng, Yanqing; Tetrahedron Letters; vol. 52; 13; (2011); p. 1477 – 1480;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com