Adding a certain compound to certain chemical reactions, such as: 19230-28-5, name is 1,3-Dichloro-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19230-28-5, Application In Synthesis of 1,3-Dichloro-2-iodobenzene
EXAMPLE 2; Preparation of S-chloro^-wopropylidene-benzonorbornadiene (Compound No. 5.26); a) n-Butyllithium variant, from l,3-dichloro-2-iodo-benzene.; To a stirred solution of l,3-dichloro-2-iodo-benzene (38.21g, 140 mmol) and 6,6-dimethyl- fulvene (46.35g, assay 96.2%, 420 mmol) in dry toluene (600 ml) under a nitrogen atmosphere, 58.8 ml of a 2.5M toluene solution of w-butyllithium (147 mmol)were added dropwise at O0C within 16 minutes. After a further 10 minutes at O0C, the reaction mixture was allowed to stand at ambient temperature overnight. Aqueous work up with saturated aqueous ammonium chloride and ethyl acetate extraction followed by washings with brine and water and drying over sodium sulphate gave a crude material which was purified by chromatography on silica gel in hexane to give 19.79g of the desired product as a yellow oil (assay 94.7% by g.l.c, 62% yield). Yellow crystals of m.p. 83-850C were obtained from cold hexane.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/68417; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com