Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
To a solution of ethyl 2-(6-nitropyridin-3-yl)acetate (33.0 g, 157 mmol) in DMF (150 mL) was added NaH (13.2 g, 330 mmol) (60 % in oil) at 0 C. The reaction mixture was allowed to warm to RT and stirred for 15 min. The mixture was cooled to 0 C again before 1,3- diiodopropane (37.3 mL, 325 mmol) was added. The resulting mixture was stirred at 0 C for 30 min, then warmed to RT and stirred for 1 h. The mixture was quenched with sat. NH4C1 (500 mL), diluted with water (500 mL), then extracted with EtOAc (500 mLx3). The combined organic layers were washed with brine (200 mL), dried over Na2SC>4, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (Petroleum ether/ EtOAc =30/ 1 to 20/ 1) to give the title compound. MS (EI) m/z 251 [M+H]+.
The synthetic route of 627-31-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; FRADERA, Xavier; HAN, Yongxin; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; WHITE, Catherine; YU, Wensheng; (89 pag.)WO2019/27856; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com