Adding a certain compound to certain chemical reactions, such as: 25309-64-2, name is 1-Ethyl-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25309-64-2, HPLC of Formula: C8H9I
To a three-necked flask was added K2CO3 (2.76 g, 20 mmol), CuI(190 mg,1 mmol), L-Proline (230 mg, 2 mmol) and DMSO, then 1-cyclopropylbutane-1,3-dione (1.17 mL, 10 mmol) and 1-ethyl-4-iodobenzene(0.724 mL, 5 mmol) were added to the mixture, which werestirred at 90 C for 18 h under N2 protection. The reaction mixture wasdissolved in water, and then extracted with ethyl acetate (3*15 mL),washed with saturated NaCl, and dried over Na2SO4. Flash columnchromatography (petroleum ether : ethyl acetate = 70:1) afforded 1(320 mg, 28.0%) as pale-yellow oily liquid.1H NMR (300 MHz, CDCl3) delta(ppm): delta 17.03 (s, 1H), 7.28 – 7.19 (m, 4H), 2.71 (t, J = 7.6 Hz, 2H),1.92 (s, 3H), 1.57 (tt, J = 7.9, 4.6 Hz, 1H), 1.30 (d, J = 7.6 Hz, 3H),1.16 (dt, J = 4.4, 3.2 Hz, 2H), 0.84 – 0.77 (m, 2H). HRMS (ESI)C15H18O2, [M + H]+ calculated = 231.1307; found = 231.1393.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Li, Xiaofang; Li, Yuyan; Peng, Kewen; Ran, Chongzhao; Xu, Yungen; Yang, Jian; Zeng, Fantian; Bioorganic and medicinal chemistry; vol. 28; 13; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com