Application of 450412-29-0, A common heterocyclic compound, 450412-29-0, name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
200 g(664 mmol) 1-bromo-3-fluoro-2-iodobenzene, 101 g (664 mmol) of 2-methoxy-phenylboronicacid and sodium tetraborate 137.5 g (997 mmol) were dissolved in 1000 ml THFand 600 ml water, and degassed. 9.3 g (13.3 mmol) of bis (triphenylphosphine)palladium (II) chloride and 1 g (20 mmol) hydrazinium hydroxide was added. The reaction mixture was stirred at 70C for 48 h under a protective gas atmosphere, cooled, washed several times with water, dried and evaporated. The reaction mixture was purified by silica gel column chromatography using toluene/heptane (2:1). Yield 155 g (553 mmol), 83%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Merck Patent GMBH; Faram, Amir Hossain; Yatsi, Anya; Evemilley, Thomas; Grossman, Tobias; Krevor, Jonas Valentine; Tobelmann, Laruese; (100 pag.)KR2016/28524; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com