Related Products of 13421-13-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13421-13-1, name is 4-Chloro-2-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: DMF (2 drops) and oxalyl chloride (180 muL, 2.12 mmol) were added to a suspension of 4-chloro-2-iodobenzoic acid (0.400 g, 1.42mmol) in toluene (5 mL). After the acid had dissolved and evolution of gas had ceased, the mixture was concentrated under vacuum to afford the crude acyl chloride, which was used without further purification.To a soln of this crude acyl chloride in CH2Cl2 (6 mL) was added a soln of Et3N (592 muL, 4.25 mmol) and aniline (129 muL,1.42 mmol) in CH2Cl2 (6 mL). The mixture was stirred for 1 h and then sat. aq NH4Cl soln (5 mL) was added. The aq layer was extracted with CH2Cl2 (3 ¡Á 5 mL) and the combined organic layers dried (Na2SO4) and evaporated. The crude residue was purified by flash chromatography (hexanes-EtOAc, 90:10 to 85:15), to afford 5e (400 mg, 79%) as a white solid. Mp 172-173 C. IR (film): 1653 (s), 1600 (s) cm-1. 1H NMR (300.13 MHz, acetone-d6): delta = 7.18 (t, J = 7.4 Hz, 1 H), 7.41 (t, J = 7.8 Hz, 2 H), 7.57 (s, 1 H), 7.83 (d, J = 7.8 Hz, 2 H), 8.00(s, 1 H), 9.55 (s, 1 H). 13C NMR (75.47 MHz, acetone-d6): delta = 93.8 (C), 120.6 (2 ¡Á CH), 124.9 (CH), 129.1 (CH), 129.6 (2 ¡Á CH), 130.0 (CH), 136.0 (C), 139.5 (CH), 139.9 (C), 143.0 (C), 167.4 (C). MS (EI): m/z (%) = 359 (7) [37Cl, M]+, 357 (20) [35Cl, M]+, 267 (25), 265 (base). HRMS (EI): m/z [M]+ calcd for C13H935ClINO: 356.9417; found: 356.9423; m/z [M]+ calcd for C13H937ClINO: 358.9388; found: 358.9385.
The chemical industry reduces the impact on the environment during synthesis 4-Chloro-2-iodobenzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Article; Madich, Youssef; Denis, J.Gabriel; Ortega, Aitor; Martinez, Claudio; Matrane, Abdellatif; Belachemi, Larbi; De Lera, Angel R.; Alvarez, Rosana; Aurrecoechea, Jose M.; Synthesis; vol. 45; 14; (2013); p. 2009 – 2017;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com