Reference of 167479-01-8, The chemical industry reduces the impact on the environment during synthesis 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, I believe this compound will play a more active role in future production and life.
Example 38; tert-Butyl r3-r{6-methoxy-4-r(2-methyl-5-{J3-(trifluoromethv?benzoyl]aminolphenv? amino]quinazolin-7-yl>oxy)propyl]carbamate; A solution of N- {3-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]-4-?iethylphenyl} -3-(trifluoromethyl)benzamide (Example 70; 100 mg, 0.213 mmol), tert-butyl (3- iodopropyl)carbamate (Method 26; 61 mg, 0.213 mmol, 1.2 equiv) and K2CO3 (44 mg, 0.320 mmol, 1.5 equiv) in MeCN (2 ml) were heated to 70 0C for 12 h. The reaction was quenched with water and extracted with EtOAc. The organics were dried with nuaCl(sat) and Na2SO4(S) and then removed under reduced pressure. The resulting solid was purified by reverse phase preparative HPLC (0.1% TFA in MeCN and water); m/z 626.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (3-iodopropyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/71963; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com