Adding a certain compound to certain chemical reactions, such as: 58313-23-8, name is Ethyl-3-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58313-23-8, Safety of Ethyl-3-iodobenzoate
General procedure: DIPEA (6 equiv) was added to a solution of propargylamine 7 (1 equiv) and the methyliodo-benzoate derivative (1.6 equiv) in THF (THF/DIPEA = 3:1). The reaction mixture wasdegassed by freeze pump thaw method, until no more gas atmosphere could be detected bythe manometer. The catalysts, Cl2Pd(PPh3)2 (2 mol %) and CuI (1 mol %) were added to thefrozen reaction mixture and the solution slowly warmed to room temperature. After 30-120 min, a colourless precipitate formed in the clear solution, indicating the progress of thereaction. At least 2-8 h later, the suspension was diluted with a saturated aqueous NH4Clsolution and KHSO4 (aq, 5 %) was added, until the organic layer started to turn faintly red(pH 5-6). The emulsion was diluted with Et2O, the organic layer separated and the organiclayer extracted to more times with Et2O. The combined organic layers were dried overNa2SO4 and the solvent was evaporated in vacuum. The crude product was purified bycolumn chromatography. Typical reactions were carried out on a scale of 0.1-0.5 g ofpropargylamine 7. Similar reactions have already been described by Hashmi [20], Ishida [21]and Wong et al. [22].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl-3-iodobenzoate, and friends who are interested can also refer to it.
Reference:
Article; Wuensch, Matthias; Schroeder, David; Froehr, Tanja; Teichmann, Lisa; Hedwig, Sebastian; Janson, Nils; Belu, Clara; Simon, Jasmin; Heidemeyer, Shari; Holtkamp, Philipp; Rudlof, Jens; Klemme, Lennard; Hinzmann, Alessa; Neumann, Beate; Stammler, Hans-Georg; Sewald, Norbert; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2428 – 2441;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com