Application of 628-21-7,Some common heterocyclic compound, 628-21-7, name is 1,4-Diiodobutane, molecular formula is C4H8I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
With reference to the above reaction formula 12, the ICH2CH2CH2CH2I (309 mg, 0 . 18mmol) containing as added to the starting material of the amine compound (amine compound, 40 mg, 0 . 15mmol), K2CO3(62 mg, 0 . 45mmol) of DMF (10 ml) solution, in 60 C mix 48 hours for reaction. Thus-prepared reaction solution, with the ice water (10 ml) after mixing, using CH2Cl2(2×20 ml) to carry out extraction. Collecting the organic layer, water (2x 10 ml) after washing, the use of non-aqueous sulfuric acid drying, to chromatographic method for the brown residue (CH2Cl2As eluant) is purified, thereby obtaining the chemical formula 27 compound (yield: 17 mg, 35%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Diiodobutane, its application will become more common.
Reference:
Patent; Shuntian Township University-Industry Association; Korea Chemical Research Institute; Song, Honyeon; Jang, Ungsig; Nam, Gungu; Li, Byeongui; Gil, Yeonsig; Li, Qiin; Sadu, Bunjabtab Seopaila; Jo, Huiyeong; (35 pag.)CN106176709; (2016); A;,
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