In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 630384-36-0, name is Methyl 1-(4-iodophenyl)cyclopropanecarboxylate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 630384-36-0
Part A. 4-Iodophenylcyclopropyl acid, methyl ester (1.40 g, 4.63 mmol) was dissolved in DMF/H2O (1:2, v/v, 5 mL total) and K2CO3 (1.28 g, 9.26 mmol, 2 eq) and was added to a slurry of Pd(OAc)2 (2.08 g, 9.26 mmol, 2 eq) under CO atmosphere (1 atm). After overnight at rt, the mixture was quenched by diluting with EtOAc and H2O. The organic layer was washed with H2O (2*). The combined aqueous layers were acidified with conc. HCl, extracted with CH2Cl2 (3*), dried over MgSO4, filtered, and concentrated under vacuum overnight to give 4-(1-methoxycarbonyl-cyclopropyl)-benzoic acid (0.987 g, yield: 97%). 1H NMR (acetone-d6) delta 7.95 (d, J=8.1 Hz, 2H), 7.46 (d, J=8.1 Hz, 2H), 3.55 (s, 3H), 1.55 (m, 2H), 1.22 (m, 2H) ppm.
The synthetic route of 630384-36-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qiao, Jennifer X.; Pinto, Donald J.; US2004/266761; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com