Electric Literature of 20555-91-3, These common heterocyclic compound, 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The terminal alkyne (1.4 mmol), PdCl2 (5.0 mol%, 0.008 g), KOAc (3.0 mmol, 0.294 g), Cr(CO)6 (1.0 mmol, 0.22 g), hydroxylamine hydrochloride (1.5 mmol, 0.104 g), and aryliodide (1.0 mmol), DMF (3.0 mL) was added to a round-bottom flask. The reaction was heated at 70 C under air and stirred for 18h. The reaction mixture was washed with water and extracted with EtOAc (3¡Á10 mL). The solvent was evaporated and the product purified by flash column chromatography (n-hexane/EtOAc gradient: 0 to 20% EtOAc) to afford the corresponding isoxazole in high yield.
Statistics shows that 1,2-Dichloro-4-iodobenzene is playing an increasingly important role. we look forward to future research findings about 20555-91-3.
Reference:
Article; Iranpoor, Nasser; Firouzabadi, Habib; Etemadi-Davan, Elham; Tetrahedron Letters; vol. 57; 8; (2016); p. 837 – 840;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com