In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-35-6, name is 2-Iodo-1,4-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9IO2
(3) Compound C (20.21 g, 98.0 mmol) was dissolved in benzene (150 mL), and 2,5-dimethoxyiodobenzene (27.16 g, 102.9 mmol), Pd (PPh3) was sequentially added at -15 C. 2Cl2 (0.69 g, 0.98 mmol), CuI (0.93 g, 4.9 mmol) and DIPEA (40 mL, 391 mmol),Then it was raised to 20 C to 30 C and stirred for 4 h.The reaction was quenched with EtOAc EtOAc (EtOAc)The combined organic layers were washed with brine (30 mL)After concentration under reduced pressure, the mixture was separated by column chromatography (hexane: ethyl acetate = 16:1).25.16 g of compound D was obtained in a yield of 75%(Rf = 0.38, n-hexane: ethyl acetate = 8:1).Among them, the detection data of compound D is as follows:
The synthetic route of 25245-35-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing University Shenzhen Sheng Yuan; Shao Wenbin; Huang Jun; Guo Kai; Zhang Weibin; Gong Jianxian; Yang Zhen; (47 pag.)CN108484638; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com