Some common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Methyl 5-bromo-2-iodobenzoate
Step1: The reactor was added 9- phenanthrene boronic acid (2.22g, 10mmol),Methyl 5-bromo-2-iodobenzoate (3.41 g, 10 mmol), Pd(PPh3)4 (0.21 g, 0.18 mmol), K2CO3 solution (2.76 g, 20 mmol), 5 mL of deionized water,13 mL of toluene and 130 mL of tetrahydrofuran were stirred and refluxed for 12 hours. After the reaction was terminated,The organic layer was separated and distilled under reduced pressure.Through silica gel column purification, and dried to give intermediate 35-1 (2.86g, 73%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 181765-86-6, its application will become more common.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Dong Xiuqin; Cai Hui; (23 pag.)CN109305943; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com