Reference of 766-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-99-4, name is 1-Ethynyl-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A 25 mL reaction flask was charged with ferrous chloride (0.05 mmol),4-iodophenylacetylene (0.5 mmol), 4-fluorobenzeneboronic acid (0.75 mmol),Sodium carbonate (1.0 mmol),Cesium hydroxide monohydrate (2.5 mmol),Sodium iodide (0.25 mmol),(0.75 mmol), & lt; / RTI & gt;Chloroform (1.5 mmol) and polyethylene glycol-400 (2.0 g),And reacted at 120 C for 6 h. Cooled to room temperature,extraction,The solvent was distilled off under reduced pressure, and the residue was isolated by column chromatography to give a yield of 87%.
The synthetic route of 1-Ethynyl-4-iodobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Normal University; HAN, WEI; DU, HONGYAN; (14 pag.)CN106116999; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com