Electric Literature of 160976-02-3, A common heterocyclic compound, 160976-02-3, name is 5-Bromo-1,3-difluoro-2-iodobenzene, molecular formula is C6H2BrF2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere, to a three-necked flask equipped with a reflux condenser were added 2,6-difluoro-4-bromoiodobenzene (13.3g, 41.67mmol),9-methyl-9H-carbazole-4-ol (18g, 91.67mmol), potassium carbonate (23g, 166.68mmol) and 200mL N-methylpyrrolidone (NMP), and heated to reflux for 6h.After the reaction, the system was cooled to room temperature. After adding a large amount of water, a white precipitate is formed, which is collected by suction filtration. The precipitate was washed sequentially with water and methanol (50% (V / V)).Finally, the obtained filter cake was dissolved in an appropriate amount of dichloromethane and further purified by column chromatography (mobile phase: petroleum ether: dichloromethane = 3: 1 (V / V)),23g of white solid was obtained with 82% yield.
The synthetic route of 160976-02-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Jiuxian New Materials Co., Ltd.; Cui Linsong; Liu Xiangyang; Zhang Yexin; Chen Hua; (56 pag.)CN110981899; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com