In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14452-30-3 as follows. Recommanded Product: 14452-30-3
General procedure: A mixture of NH4Cl (0.14 g, 2.5 mmol), 1-(pyridin-2-yl)ethan-1-one (0.6 g, 5.0 mmol), and 20.0 mL of acetonitrile wasstirred for 5 minutes, then DCDMH (1.95 g, 10 mmol) was added, the mixture was stirred for 16 hours at 40 oC. Aftercompletion of the reaction, solvent was removed and ethyl acetate (20 mL) was added. Then the ethyl acetate was washedtwice with water (20 mL), the organic phase was dried over anhydrous sodium sulfate and subsequently the solvent wasevaporated under reduced pressure. The residues were purified by silica gel column chromatography to give 10 as yellowoil. Yield: 78.7 %.
According to the analysis of related databases, 14452-30-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Zhang, Shao-Lin; Yang, Zheng; Hu, Xiaohui; Tam, Kin Yip; Bioorganic and Medicinal Chemistry Letters; vol. 28; 21; (2018); p. 3441 – 3445;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com