Related Products of 1437316-91-0, A common heterocyclic compound, 1437316-91-0, name is 2,4-Difluoro-3-iodoaniline, molecular formula is C6H4F2IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2,4-difluoro-3-iodoaniline (255 mg, 1 mmol) in 1,2_dichloroethane (3 mL) was slowly added dropwise a solution of P to pyridine (lmL), propylsulfonyl chloride (157 mg, 1. lmmol). The reaction solution was heated under reflux for 2 hours, cooled and concentrated in vacuo to remove the solvent. The resulting oil was dissolved in ethyl acetate (20 mL) and washed with 5% sodium bicarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give N- (2,4-difluoro-3- Iodophenyl) propane-1-sulfonamide (298 mg, 83%).
The synthetic route of 1437316-91-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Sai Lintai Pharmaceutical Co., Ltd.; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Xiao Dengming; Li Jijun; Zhu Yan; Hu Yuandong; Wang Huting; Wang Zhe; Wang Zanping; Wei Yongheng; Sun Yinghui; Wu Qiong; Zhang Hui; Peng Yong; Kong Fansheng; Sun Ying; Luo Hong; Han Yongxin; (64 pag.)CN103102349; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com