Reference of 181765-86-6, A common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[Intermediate 1-a] was synthesized according to Scheme 1 below.Methyl 5-bromo-2-iodobenzoate (25.0 g, 73 mmol) in a 500 mL round bottom flask reactorAdd 4-dibenzofuranboronic acid (18.7g, 88mmol), tetrakis (triphenylphosphine) palladium (1.7g, 0.15mmol), potassium carbonate (20.2 g, 146.7mmol), 125mL toluene, 125mL tetrahydrofuran 50 mL of water was added thereto.The temperature of the reactor was raised to 80 degrees and stirred for 10 hours. After the reaction was completed, the temperature of the reactor was lowered to room temperature, extracted with ethyl acetate, and the organic layer was separated.The organic layer was concentrated under reduced pressure and separated by column chromatography to obtain Intermediate 1-a (75.0 g, 60.1%).
The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SFC Ltd.; Cha Sun-uk; Jeong Gyeong-seok; Song Ju-man; Lee Yu-rim; Park Sang-u; Kim Hui-dae; Park Seok-bae; (65 pag.)KR2019/111856; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com