Application of 170112-66-0, The chemical industry reduces the impact on the environment during synthesis 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, I believe this compound will play a more active role in future production and life.
3,4,5-fluoro-iodobenzene (10.0g, 38.0mmol), bromo difluoroethyl acetate (23.1g, 114mmol) and copper (2.90g, 45.6mmol) and stirred for 3 h with dimethyl sulfoxide solution (40ml) 80 of.Ethyl acetate was added to the reaction mixture, the insoluble matter was separated by filtration.Pour the water filtrate was extracted with ethyl acetate.The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The concentrate was purified by silica gel column chromatography and purified by (elution solvent ethyl acetate / n-hexane = 1/10) to give the title compound as a colorless oil (yield 7.20 g, 75% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trifluoroiodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hokko Chemical Industry; Suzuki, Jun; Hiroki, Eisho; Nonaka, Hisato; (15 pag.)JP2016/84346; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com