Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2265-91-0
A mixture of 8-{[tert-butyl(dimethyl)silyl]oxy}-2-azaspiro[4.5]decan-1 -one (isomer 1) (425 mg,1.50 mmol), 1,3-difluoro-5-iodobenzene (360 mg, 1.50 mmol, GAS No 2265-91-0), copper(l)iodide (143 mg, 0.750 mmol), N,N?-dimethylethylenediamine (164 p1, 1.50 mmol) andpotassium carbonate (435 mg, 3.15 mmol) in dioxane (26 ml) was heated to 1600 for 2 h ina microwave reactor. Upon cooling, the reaction mixture was filtrated through a pad of celite, and the filtrate was concentrated and the residue was purified by flash chromatography (25 g Snap Gartrige, hexanes/ethyl acetate-gradient, 0% -> 50% ethyl acetate) to give the title compound as single isomer (575 mg).LG-MS (Method 2): R = 1.79 mm; MS (ESIpos): m/z = 396.3 [M+H]1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 7.50-7.41 (m, 2H), 6.98-6.91 (m, 1H), 3.94-3.88(m, 1H), 3.72 (t, 2H), 2.00-1.85 (m, 4H), 1.63-1.47 (m, 4H), 1.28-1.20 (m, 2H), 0.85 (5, 9H),0.01 (5, 6H)
According to the analysis of related databases, 2265-91-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com