Synthetic Route of 4949-69-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4949-69-3, name is 4-Iodo-3-methylaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-iodo-5-aminotoluene (10 g, 43.1 mmol) in THF (200 ml) was added sodium bicarbonate (10.81 g, 128.76 mmol) and Boc2O (14.09 g, 64.66 mmol) and the reaction mixture was stirred at 50 C for 12 h. The reaction mixture was then cooled to room temperature, filtered and concentrated under reduced pressure. The residue was partitioned between brine and AcOEt and the aqueous layer was extracted with AcOEt. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give 10 g (yield 69%) of brown solid corresponding to tert-butyl 4-iodo-3-methylphenylcarbamate. The crude product was used in the next step without further purification. Mass: (ES+) C12H16INO2 required 333.02; found 332 [M-H], HPLC/MS method 4.
The synthetic route of 4-Iodo-3-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENOSCIENCE PHARMA; BRUN, Sonia; BERET, Antoine; BASSISSI, Firas; HALFON, Philippe; COURCAMBECK, Jerome; (275 pag.)WO2017/191599; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com