Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 618-91-7, name is Methyl 3-iodobenzoate, A new synthetic method of this compound is introduced below., Safety of Methyl 3-iodobenzoate
3-iodo-benzoic acid methyl ester (1g, 3.82mmol), piperidine (0.76 ml, 7 . 63mmol), potassium carbonate (2.11g, 15 . 26mmol), cuprous iodide (0.15g, 0 . 76mmol), L-proline (0.18g, 1 . 53mmol)-miscible in 20mlDMSO in, under the protection of nitrogen heating 60 C reaction 8h, water 200 ml dilution, using ethyl acetate (30 ml ¡Á 3) extraction, combined with the phase, to saturated salt water (15 ml ¡Á 2) washing, dry anhydrous sodium sulfate, filtered, the filtrate may be amber oily evaporating solvent under reduced pressure, column chromatography (petroleum ether/ethyl acetate, 95:5, v/v) purified VI-10.61g colorless oily, yield 84%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CHINA PHARMACEUTICAL UNIVERSITY; HUANG, WENLONG; QIAN, HAI; LI, ZHENG; YANG, JIANYONG; SU, XIN; PAN, MIAOBO; (18 pag.)CN105566263; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com