Application of 5471-81-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5471-81-8 as follows.
To a stirred solution of 18-2B (3.2 g, 11.5 mmol; TCI) in THF was treated with isopropyl magnesium chloride (/-PrMgCl) in THF (22.8 mL of 2.0 M in THF, 46 mmol) at -15 C. After 2 hr stirring at the same temperature, dry DMF (4.3 mL, 57.5 mmol) was added and the reaction was allowed to warm to 23 C over 1 hr. After consumption of the starting material (by TLC), the reaction was quenched with aqueous 1M HC1 (60 mL), followed by extracted with EtOAc, dried over Na2S04 and concentrated. The crude compound was purified by flash column chromatography (100-200 silica) using 5% EtOAc in hexanes to afford 18-3B (1.4 g, 7.8 mmol, 70% yield) as an off-white solid. MS (ESI): m z 179.2 (M+l)+.
According to the analysis of related databases, 5471-81-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; COCRYSTAL PHARMA, INC.; JACOBSON, Irina C.; FEESE, Michael D.; LEE, Sam S.; (169 pag.)WO2016/154241; (2016); A1;,
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