Application of 618-91-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 618-91-7, name is Methyl 3-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Obtained in Step 1 3-iodobenzoic acid methylester (104) and (3.04 g) was dissolved in THF (24 mL), PdCl2 (PPh3) 2 (244 mg), CuI (133 mg), triethylamine (. 6 mL ), was added trimethylsilylacetylene (1.37 g), under an argon atmosphere and stirred at room temperature for 26 hours. Thereaction mixture was filtered, the filtrate was concentrated, the residue was purified by silica gel flash column chromatography(developing solvent n-hexane:ethyl acetate = 50: 1) to give the title compound (2.42 g, 90% yield) white It was obtained as asolid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nagoya City University; Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Ida, Shinsuke; Rie, Masaki; (47 pag.)JP5725475; (2015); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com