Introduction of a new synthetic route about 51628-12-7

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Adding a certain compound to certain chemical reactions, such as: 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51628-12-7, Safety of 2-(4-Iodophenyl)acetonitrile

By using the synthesis method described in PTL 16, the same compound was also obtained even using 5-methylmenthyl amide (14a-50) obtained in Example 1, copper iodide, phosphoric acid, and 4-iodobenzyl cyanide (yield: 43%).

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Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; ITOH, Hisanori; HORI, Yoji; OTSUKA, Masashi; MATSUMOTO, Takaji; SATO, Tomoharu; (50 pag.)US2018/57447; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com