Application of 56404-21-8, The chemical industry reduces the impact on the environment during synthesis 56404-21-8, name is 1-Iodo-2,4-dimethyl-3-nitrobenzene, I believe this compound will play a more active role in future production and life.
To a solution of 2,4-dimethyl-3-nitroiodobenzene (14Og, 0.51mol), acrolein diethylactal (229ml, 1.5mol), W-Bu4NCl (139g, 0.5mol), ?-Bu3N (238ml, l .Omol) in 2000ml of DMF, Pd(OAc)2 (3.4g, 0.015mol) was added. The mixture was warmed at 90 0C and stirred for 2 hours. After cooling, the reaction mixture was diluted with 2N HCl and extracted with diethyl ether. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was used for next step without further purification. An analytically pure sample was obtained by chromatography (ISCO, hexane/ethyl acetate, 0-30%, 40 min). 1H- NMR delta (DMSO-d6, 300MHz): 7.27 (d, J=7.8Hz, IH), 7.16 (d, J=7.8Hz, IH), 4.03 (q, J=7.2Hz, 2H), 2.87 (t, J=7.8Hz, 2H), 2.57 (t, J=7.8Hz, 2H), 2.16 (s, 3H), 2.13 (s, 3H), 1.14 (t, J=7.2Hz, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2,4-dimethyl-3-nitrobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VALEANT PHARMACEUTICALS INTERNATIONAL; WO2008/66900; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com