In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35944-64-0, name is 3-Iodo-4-methylaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H8IN
To a solution of 3-iodo-4- methyl aniline (0.7 equiv) in THF under nitrogen atmosphere was added 3-trifluoro methyl benzoyl chloride (1 equiv, prepared from the reaction of 3- trifluoromethyl benzoic acid and SOCl2) in THF at room temperature during 30minutes followed by drop wise addition of (i-Pr)2EtN (4 equiv) and 4-DMAP (0.2 equiv). After stirring at ambient temperature for 3h, the reaction mixture was quenched with water. The resulting mixture was extracted with ethyl acetate, concentrated and the compound was isolated by adding n-hexane.
The synthetic route of 35944-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NATCO PHARMA LIMITED; KOMPELLA, Amala; GAMPA, Venugopala Krishna; GANGANAMONI, Srinivasulu; SIRIGIREDDY, Balakrishna Reddy; ADIBHATLA, Kali Satya Bhujanga Rao; NANNAPANENI, Venkaiah Chowdary; WO2015/186137; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com