In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 452-82-4 as follows. Formula: C7H6FI
A mixture of 4-fluoro-3-iodotoluene (5.0 g, 21.2 mmol) and NBS (4.2 g, 23.3 mmol) in 50 mL of CCl 4 was refluxed under N 2 with benzoyl peroxide (250 mg, 1.03 mmol) was heated for 3 hours. The reaction mixture was cooled to room temperature and filtered through celite, washed with benzene. The filtrate was evaporated and pumped to give the benzylbromide as a crude light brown oil. [0192] A mixture of benzylbromide in 50 mL of DMSO was heated with NaHCO 3 solid (3.55 g, 42.2 mmol) at 120¡ã C. for 90 min. The reaction mixture was then cooled to room temperature, quenched with water, extracted with Et 2O, and washed with water, brine. The organic layer was dried with Na 2SO 4, concentrated in vacuuo. MPLC purification provided the titled compound as a colorless oil which solidified over time (2.2 g, 41.5% over two steps).
According to the analysis of related databases, 452-82-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xin, Zhili; Liu, Gang; Pei, Zhonghua; Szczepankiewicz, Bruce G.; Serby, Michael D.; Zhao, Hongyu; US2004/214870; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com