Adding a certain compound to certain chemical reactions, such as: 774608-49-0, name is 4-Bromo-1-chloro-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 774608-49-0, name: 4-Bromo-1-chloro-2-iodobenzene
Example 3: Preparation of 4-[l-(5-bromo-2-chlorophenyl)-lH-imidazol-4-yl]-benzonitrile.The compound was prepared according to Liu et al. J. Org. Chem. 2005, 70, 10135. 4-(lH-Imidazol-4-yl)-benzonitrile (75 mg, 0.44 mmol; prepared from 4-(2-bromo-acetyl)- benzonitrile using the method of Lynch et al. J. Am. Chem. Soc. 1994, 116, 11030), 4-bromo- l-chloro-2-iodobenzene (169 mg, 0.532 mmol), Cs2CO3 (577 mg, 1.77 mmol), CuI (3 mg, 0.013 mmol), 8-hydroxyquinoline (2 mg, 0.013 mmol), and DMF/Eta2O (2 mL; 10:1 solution) were combined in a 10 mL CEM Microwave reaction vessel fitted with magnetic stir bar and subjected to microwave irradiation at 150 0C for 30 min. The contents were then filtered and concentrated to dryness affording intermediate 5-bromo-2-chlorophenyl)-lH-imidazol-4-yl]- benzonitrile (68 mg, 43%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-chloro-2-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; DOW AGROSCIENCES LLC; LAMBERT, William; CROUSE, Gary; SPARKS, Thomas; CUDWORTH, Denise; WO2011/17513; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com