618-91-7, name is Methyl 3-iodobenzoate, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Methyl 3-iodobenzoate
To Methyl 3-iodobenzoate (25.0 g, 95.41 mmol) in ethanol (120.0 ml) was added hydrazine hydrate (50.0 ml). The reaction mixture was reflux for 18 hours. Heating was stopped and then water (300.0 ml) was added. After cooling down to room temperature, white solid was appeared. The white product solid was collected by filtration. The product was washed with water and dried under vacuum. Final white pure product was obtained in 23.0 g (92.0%). 1H NMR (400 MHz, DMSO-de, delta): 9.85 (s, br, 1 H, NH), 8.14 (t, J = 1.6 Hz, 1 H), 7.85 (m, 1 H), 7.82 (m, 1 H), 7.25 (t, J = 8.0 Hz, 1 H), 4.50 (s, 2 H, NH2). 13C NMR (100 MHz, CDCl3) delta: 168.54, 155.38, 129.54, 126.72, 125.57, 34.90, 31.07.
The synthetic route of 618-91-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; ZHANG, Yadong; ZUNIGA, Carlos; DESHAYES, Gaelle; LEROY, Julie; BARLOW, Stephen; MARDER, Seth, R.; KIM, Sung-Jin; KIPPELEN, Bernard; WO2010/149620; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com