Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 5471-81-8
Under the protection of inert gas,Pd(OAc)2 (2.2 mg, 10 mol%), XPhos (19.1 mg, 20 mol%), NBE-CO2K (3.5 mg, 10 mol%) were added to a 4.0 mL reaction flask which was dried and equipped with a magnetic stir bar.Methyl 3-methyl-4-iodobenzoate (0.2 mmol, 1.0 equiv.),Phenyl glycidyl ether (0.6 mmol, 3.0 equiv.) and dry N-methylpyrrolidone (1.0 mL). The reaction flask was capped and stirred at room temperature for about 5 minutes, after which the mixture was heated to 80 C and stirred for 24 hours. After cooling the reaction vessel to room temperature, it was quenched with water (10 mL).Extracted with methyl tert-butyl ether (3 ¡Á 10 mL), dried with Na 2 SO 4Filter and concentrate under vacuum. Purified by column chromatography,The eluent is petroleum ether: ethyl acetate = 10:1 (v/v),49 mg of methyl 7-methyl-2-(phenoxymethyl)-2,3-dihydrobenzofuran-5-carboxylate (white solid, yield 82%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Wuhan University; Zhou Qianghui; Wu Chenggui; Cheng Honggang; (20 pag.)CN108329285; (2018); A;,
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