Synthetic Route of 188815-32-9,Some common heterocyclic compound, 188815-32-9, name is 3-Bromo-5-iodobenzoic acid, molecular formula is C7H4BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-bromo-5-iodobenzoic acid (50g, 153mmol), 1- (3-dimethylaminopropyl)- ETHYLCARBODIIMIDE hydrochloride (30.8g, 153MMOL), 4-dimethylaminopyridine (18. 6g, 153MMOL) and t-butanol (69.4g, 90MOI, 153MMOL) in dichloromethane (500ml) was stirred at room temperature overnight. The reaction mixture was washed with 2MHCI and saturated NaHCO3 The organic phase was dried and evaporated to give the title compound as a light brown solid (48g, 85%). 1H NMR: (CDCI3) delta: 1.58 (9H, s), 7.99 (1 H, s), 8.05 (1 H, s), 8.22 (1 H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-5-iodobenzoic acid, its application will become more common.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39753; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com