Application of 19094-56-5,Some common heterocyclic compound, 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, molecular formula is C7H4ClIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(282 g, 1 mol) of 5-iodo-2-chlorobenzoic acid, 1.0 L of dichloromethane, (142.8 g, 1.2 mol) of thionyl chloride and a catalytic amount of DMF were added to the reaction flask.The temperature was raised to 39 ¡ã C – 42 ¡ã C for 3 hrs – 5 hrs. Cool down to 5-10 ¡ã C,(160 g, 1.2 mol) of aluminum trichloride and (125 g, 1.3 mol) of fluorobenzene were added.The reaction was heated to reflux overnight. After the reaction, cool down to 0 ¡ã C,The reaction was quenched by dropwise addition of 100 ml of 6N hydrochloric acid.Add 400ml of water to the organic phase,The organic phase is treated with 400 ml of saturated sodium bicarbonate solution.Wash with 400 ml of saturated sodium chloride solution and dry over anhydrous sodium sulfate.Concentrate to dryness, add 100ml of absolute ethanol to heat and dissolve, and cool down to 5-10 ¡ãC.Insulation crystallization for 2h, suction filtration,Dry white solid(5-iodo-2-chlorophenyl)(4-fluorophenyl)methanone 310 g.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-5-iodobenzoic acid, its application will become more common.
Reference:
Patent; Hangzhou Keyao Pharmaceutical Technology Co., Ltd.; Zhou Junming; Liu Yanzhen; Luo Hao; (8 pag.)CN108752184; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com