Related Products of 20555-91-3, These common heterocyclic compound, 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: An efficacious one-pot synthesis method reported by Bielawskiet al. (2007) was adopted with minor modifications in this section. The overall route is shown in Scheme 2, andthe obtained compounds listed in Fig. 2. Briefly, to a 50-mL round-bottomed flask was added substituted iodobenzene(5 mmol), 20 mL of DCM, and mCPBA 1.22 g(6 mmol, 85% purity), followed by the slow addition of(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene 1.31 mL(6 mmol). After cooling the mixture to 0 C, trifluoromethanesulfonic acid 0.75 mL (8.5 mmol) was added dropwise into the system. The resulting solution wasstirred at room temperature for 2 h. The crude product was purified by column chromatography on silica gel eluted with a mixture of DCM:methanol (20:1, vol.) to yield the desired products.
Statistics shows that 1,2-Dichloro-4-iodobenzene is playing an increasingly important role. we look forward to future research findings about 20555-91-3.
Reference:
Article; Huang, Mengen; Xu, Shujia; Wu, Xunshen; Zhao, Min; Wang, Limin; Journal of Surfactants and Detergents; vol. 21; 3; (2018); p. 323 – 334;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com