In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 869500-07-2 as follows. Formula: C7H6BrI
29.7 g of 1-bromo-2-iodo-3-toluene was dissolved in 300 ml of 1,4-dioxane solvent.Stirring under nitrogen, adding 20.2 g of o-bromobenzeneboronic acid,34.5 g of K2CO3, 1.15 g of tetrakis(triphenylphosphine)palladium, and the temperature was raised to reflux.After 5 hours, the basic reaction of the raw materials was determined by HPLC, and the reaction solution was dried under reduced pressure.The residue was subjected to column chromatography to give Intermediate 22-1 as 22.1 g (0.068 mol). (Yield: 81%)
According to the analysis of related databases, 869500-07-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Feng Yu; Jia Xueyi; (40 pag.)CN108409773; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com